B Tier
Blood Rune
Bleed DoT Damage
Inflicts a bleed effect on enemies, dealing damage over 5 seconds. Blood Rune scales from 65% bleed damage at base to 97% at max level. Longer duration than Inferno Rune but slightly lower total damage.
Updated 2026-03-15
Tier Position
#8 of 11
Location
Rune Dungeon — rare drop
Max Level
Lv50
Cost
Free (drop)
At a Glance
Blood Rune
B Tier
Ranked #8 of 11 in Runes
Bleed DoT Damage
Tier Distribution
S+
2
18%
S
3
27%
A
1
9%
B
3
27%
C
1
9%
D
1
9%
Blood Rune is in B Tier
Bonus & Scaling
| Bonus Type | Bleed DoT Damage |
| Scaling | Base: 65% total DMG over 5s → Max (Lv50): 97% total DMG over 5s |
| Location | Rune Dungeon — rare drop |
| Cost (Fragments) | Free (drop) |
Rune Leveling
Max Level
Lv50
Duplicates Needed
502
Equip Limit
1 Rune
Runes are leveled by feeding duplicate copies. Each level increases the rune's bonus. Only one rune can be equipped at a time, so choose wisely.
Usage Tips
- •Damage runes are the most versatile choice, boosting all damage output universally.
- •Pairs well with high-DPS fruits and swords for maximum burst damage.
- •DoT (Damage over Time) runes provide sustained damage, great for extended boss fights.
- •Less effective in PvP where burst damage is preferred over sustained damage.
- •Only one rune can be equipped at a time. Prioritize leveling your primary rune to Lv50 before investing in others.
BleedDotDamageBoss-Farming
Synergy Recommendations
Best Fruits to Pair
Dragon Fruit
PvP synergy
Fiend Fruit
PvP synergy
Kitsune Fruit
PvP synergy
Light Fruit
PvP synergy
Best Races to Pair
SwordBlessed
PvP race
Galevorn
PvP race
Sunborn
PvP race
Servant
PvP race
Recommended Builds
Warlord + Strongest Shinobi
EndgameSwordBlessed + Gilgamesh
PvPGalevorn + Anos
EndgameLeviathan / Servant
EndgameRelated Content
All Runes Database
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View Blood Rune on Runes Tier List
See where Blood Rune ranks among all runes.
Best Builds with Blood Rune
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Active Codes
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Build Optimizer
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Accessories Wiki
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